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Home > Endocrinology/Hormones > Androgen Receptor > Galeterone
Galeterone  
Catalog No. T6509    CAS 851983-85-2
Pack Size
Availability
Price/USD
Quantity
5mg
In stock
60.00
10mg
In stock
90.00
25mg
In stock
162.00
50mg
In stock
270.00
100mg
Inquiry
450.00
1 mL * 10 mM (in DMSO)
In stock
60.00
Bulk Size: Please Quote for Discount
Documents and Quality Management
Purity:99.77% COA Datasheet HNMR HPLC
Biological Activity:

Product Description:

Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.

Target:
CYP17; Androgen Receptor;
Research Area:
Cancer
Chemical Information:
Molecular Weight 388.55
Formula C26H32N2O
CAS Number 851983-85-2
Solubility DMSO:19.4 mg/mL (50 mM);Ethanol:19.4 mg/mL (50 mM)
Storage 3 years -20°C powder;
2 years -80°C in solvent;
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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Reference

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