Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-inflammatory activities.
(RS)-Sakuranetin is the racemic form of Sakuranetin, exhibiting μM-level antagonism toward adenosine receptors and inhibitory effects on KB and P-388 cells.
Ethyl linolenate is a fatty acid ethyl ester that exhibits anti-melanogenic properties by suppressing cellular melanin synthesis with an IC50 of 70 μM.Ethyl linolenate inhibit forskolin-stimulated melanogenesis and reduces tyrosinase enzymatic activity. Its antimelanogenic profile supports the utilization of Ethyl linolenate in pigmentation disorder research and skin-lightening mechanism studies.