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trans-C75

Catalog No. T10656 CAS 191282-48-1

Synonyms: (±)-C75

trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).

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trans-C75, CAS 191282-48-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 63.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 353.00
50 mg	In stock	$ 565.00
100 mg	In stock	$ 793.00
1 mL * 10 mM (in DMSO)	In stock	$ 110.00

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Purity: 98.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).
Targets&IC50	PC3 cells:35 μM (IC50)
In vitro	Treatment with C75 alone decreased clonogenic survival, an effect that was abrogated by the antioxidant. C75 treatment also delayed spheroid growth in a concentration-dependent manner. The radiosensitizing effect of C75 was indicated by combination index values between 0.65 and 0.71 and the reduced surviving fraction of clonogens, in response to 2 Gy X irradiation, from 0.51 to 0.30 and 0.11 in the presence of 25 and 35 μM C75, respectively. This increased sensitivity to radiation was reduced by the presence of the antioxidant. The C75 treatment also enhanced the spheroid growth delay induced by X irradiation in a supra-additive manner. The level of radiation-induced apoptosis in prostate cancer cells was increased further by C75, which induced cell cycle arrest in the G2/M phase, but only at a concentration greater than that required for radiosensitization.

Synonyms	(±)-C75
Molecular Weight	254.32
Formula	C14H22O4
CAS No.	191282-48-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.3 mg/mL (327.54 mM), Sonification and heating are recommended.

References and Literature

1. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. 2. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Metabolism Compound Library NO PAINS Compound Library Covalent Inhibitor Library Metabolism Compound Library Lipid Metabolism Compound Library Bioactive Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max

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Keywords

trans-C75 191282-48-1 Metabolism Others Fatty Acid Synthase C 75 (±)-C75 trans-C-75 Fatty Acid Synthase (FASN) Inhibitor C-75 inhibit trans C75 transC75 C75 inhibitor

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