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p-Hydroxy-cinnamic acid

Catalog No. T7053
Synonyms: p-Coumaric acid, p-Cumaric acid, NSC 59260
Purity 99.55% Datasheet

p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.

p-Hydroxy-cinnamic acid, CAS 7400-08-0
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Biological Description
Chemical Properties
Storage & Solubility Information
Description p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
Targets&IC50 prostaglandin E2 :ic50 126 μM,   thromboxane B2 :ic50 371 μM,  

Description

p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.

Targets&IC50

prostaglandin E2 :ic50 126 μM

thromboxane B2 :ic50 371 μM

In Vitro

p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55•2 (SE 4•01) % and 35•6 (SE 2•35) % relative to the basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary hemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1].

Synonyms p-Coumaric acid, p-Cumaric acid, NSC 59260
Purity 99.55%
Appearance solid
Molecular Weight 164.16
Formula C9H8O3
CAS No. 7400-08-0
SMILES data to be upload

Storage

Powder: -20°C, 3years; 4°C, 2 years

In solvent: -80°C, 6 months; -20°C, 1 month

Solubility Information

DMSO: 201 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Luceri C, et al. p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. Br J Nutr. 2007 Mar;97(3):458-63.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Natural Compound Library for HTS Selected Plant-sourced Compound Library

Related Products

Related compounds with same targets
Grapiprant ONO-AE3-208 Lusutrombopag Tafluprost E7046 Saikogenin D Pseudohypericin Polygalacin D

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