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gamma-DGG acetate(6729-55-1 free base)

Catalog No. T15369L   CAS 2935387-13-4
Synonyms: γDGG, γ-D-Glutamylglycine

gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.

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gamma-DGG acetate(6729-55-1 free base) Chemical Structure
gamma-DGG acetate(6729-55-1 free base), CAS 2935387-13-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 48.00
10 mg In stock $ 65.00
50 mg In stock $ 119.00
100 mg In stock $ 189.00
200 mg In stock $ 283.00
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Purity: 99.81%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.
In vitro gamma-DGG (γ-DGG) acetate is the most effective antagonist of the excitatory postsynaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p.gamma-DGG blocks less at higher glutamate concentration. gamma-DGG (200-400 μM) in the bath decreases the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses) and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left[1]. The quantal analysis displays that the reduction in the e.p.s.p. paralleled the reduction in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG[2].
Synonyms γDGG, γ-D-Glutamylglycine
Molecular Weight 264.23
Formula C9H16N2O7
CAS No. 2935387-13-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

TargetMolReferences and Literature

1. Wu XS, et al. The origin of quantal size variation: vesicular glutamate concentration plays a significant role. J Neurosci. 2007 Mar 14;27(11):3046-56. 2. Crunelli V, et al. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus. J Physiol. 1983 Aug;341:627-40.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library NO PAINS Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max Inhibitor Library Neuronal Signaling Compound Library

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Keywords

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