Powder: -20°C for 3 years | In solvent: -80°C for 1 year
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 372.00 | |
50 mg | In stock | $ 556.00 | |
100 mg | In stock | $ 783.00 | |
500 mg | In stock | $ 1,650.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 155.00 |
Description | dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis. |
Targets&IC50 | BET:430 nM (EC50) |
In vitro | dBET1 induced a potent and superior inhibitory effect on MV4;11 cell proliferation at 24 hours (measured by ATP content, IC50 = 0.14 μM, compared to IC50 = 1.1 μM with JQ1) consistent with the reported, pronounced inhibitory effect of RNA silencing of BRD4 in this and other models of MLL-rearranged leukemia. |
Molecular Weight | 785.27 |
Formula | C38H37ClN8O7S |
CAS No. | 1799711-21-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL
H2O: Insoluble
Ethanol: 5 mg/mL
You can also refer to dose conversion for different animals. More
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dBET1 1799711-21-9 Chromatin/Epigenetic Epigenetic Reader Domain inhibit PROTACs Inhibitor dBET 1 dBET-1 inhibitor