Albaconol

Albaconol is a natural product of the prenylated resorcinol class isolated from Albatrellus confluens. Albaconol exhibits multiple biological activities, inducing apoptosis through inhibition of NF-κB and DNA topoisomerase II, while acting as a weak antagonist of hVR1/rVR1 (IC₅₀ of 17 μM and 5.5 μM, respectively), showing potential application value in tumor suppression and pain research.

Method: K562, A549, BGC-823 and Bcap-37 cancer cells were exposed to Albaconol, and cell growth and DNA-topoisomerase-mediated cleavage and relaxation were assessed.
Result: Cellular IC₅₀ values were 7.99±0.40, 3.17±0.89, 4.18±0.14 and 7.45±2.50 μM, respectively; albaconol stabilized topoisomerase-II cleavable complexes and interfered with DNA religation but did not inhibit topoisomerase I.^[1]
Method: Isolated guinea-pig tracheal strips were exposed to albaconol, with or without the vanilloid-receptor antagonist capsazepine.
Result: Albaconol induced contraction followed by desensitization, with a pEC₅₀ of 4.23±0.18; capsazepine antagonized the response, supporting partial vanilloid-receptor agonism.^[2]
Method: RAW264.7 macrophages were treated with albaconol before inflammatory stimulation, and cytokines, NF-κB activation, SOCS1 expression, antigen presentation and viability were measured.
Result: Albaconol suppressed TNF-α, IL-6 and IL-1β production and NF-κB activation, increased SOCS1 and reduced macrophage antigen-presentation activity; higher concentrations induced apoptosis.^[3]