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ADX68692
(Synonyms: ADX 68692) Copy Product Info
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Synonyms: ADX 68692
Catalog No. T217657 Copy Product Info
Purity: 99.59%
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ADX68692 is an orally active negative allosteric modulator that targets the follicle-stimulating hormone receptor (FSHR). ADX68692 exerts its regulatory effect primarily by inhibiting FSHR-mediated cAMP production and can be used in research into reproductive system disorders associated with abnormal FSH/FSHR signalling.
Cas No. 1067191-08-5
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| Pack Size | Price | EUR Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | 175 € | - | In Stock | |
| 5 mg | 434 € | - | In Stock | |
| 10 mg | 621 € | - | In Stock | |
| 25 mg | 972 € | - | In Stock | |
| 50 mg | 1.341 € | - | In Stock |
For In stock only · Estimated delivery: EUR Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.59%
Appearance:Solid
Color:Yellow
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ADX68692 is an orally active negative allosteric modulator that targets the follicle-stimulating hormone receptor (FSHR). ADX68692 exerts its regulatory effect primarily by inhibiting FSHR-mediated cAMP production and can be used in research into reproductive system disorders associated with abnormal FSH/FSHR signalling. |
| In vivo | Method: Mature female rats received ADX68692 by oral gavage at 10 or 25 mg/kg. Estrous cycling and FSH-induced progesterone, estradiol, oocyte release and preovulatory follicle formation were evaluated.Result: Both doses disrupted estrous cycling. At 25 mg/kg, ADX68692 reduced FSH-induced progesterone and estradiol production, oocyte release and formation of preovulatory follicles.[1] |
| Synonyms | ADX 68692 |
| Molecular Weight | 401.4577 |
| Formula | C24H23N3O3 |
| Cas No. | 1067191-08-5 |
| Smiles | COC1=C(OC)C=C(C=C1)C(=O)NC1=CC(C2=CN=CC=C2)=C(C=C1)C(C)(C)C#N |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: ADX68692 chemical structure | ADX68692 in vivo | ADX68692 formula | ADX68692 molecular weight
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