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WEHI-539 hydrochloride

Catalog No. T13337   CAS 2070018-33-4

WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).

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WEHI-539 hydrochloride Chemical Structure
WEHI-539 hydrochloride, CAS 2070018-33-4
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Biological Description
Chemical Properties
Storage & Solubility Information
Description WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
Targets&IC50 BCL-XL:1.1 nM
In vitro WEHI-539 hydrochloride is a selective Bcl-XL inhibitor. WEHI-539 augments NSC 241240 induced caspase 3/7 activity, PARP cleavage and annexin V labelling. WEHI-539 as a single agent causes noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells[2].
Molecular Weight 620.18
Formula C31H30ClN5O3S2
CAS No. 2070018-33-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (80.62 mM), sonification is recommended.

TargetMolReferences and Literature

1. Lessene G, et al. Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol. 2013 Jun;9(6):390-7. 2. Abed MN, et al. Antagonism of Bcl-XL is necessary for synergy between NSC 241240 and BH3 mimetics in ovarian cancer cells. J Ovarian Res. 2016 Apr 14;9:25.

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Keywords

WEHI-539 hydrochloride 2070018-33-4 Apoptosis BCL WEHI-539 Hydrochloride WEHI 539 hydrochloride WEHI539 Hydrochloride WEHI 539 Hydrochloride WEHI539 hydrochloride inhibitor inhibit

 

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