Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 197.00 | |
5 mg | In stock | $ 457.00 | |
10 mg | In stock | $ 666.00 | |
50 mg | In stock | $ 1,460.00 | |
100 mg | In stock | $ 1,970.00 | |
200 mg | In stock | $ 2,660.00 |
Description | Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6). |
Targets&IC50 | CDK6-CyclinD3:4 nM, CDK4-CyclinD1:1 nM |
In vitro | Incubation with Trilaciclib hydrochloride (G1T28) for 24 hours can induce a strong G1 cell cycle arrest (time=0). Cells have re-entered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells By 16 hours after Trilaciclib hydrochloride washout. These results demonstrate that Trilaciclib hydrochloride causes a transient, and reversible G1 arrest. A transient Trilaciclib hydrochloride-mediated G1 cell-cycle arrest in CDK4/6-sensitive cells decreases the in vitro toxicity of a variety of commonly used cytotoxic chemotherapy agents associated with myelosuppression. |
In vivo | G1T28 inhibits the phosphorylation of RB and induces an exclusive, reversible G1 arrest.n vivo, G1T28 reversibly and in a dose-dependent manner, regulates the proliferation of HSPCs.Pretreatment of mice with oral G1T28 allows for the faster recovery of CBCs following chemotherapy treatment.Likewise, oral G1T28 does not protect RB-deficient tumors from chemotherapy but adds to the antitumor effect.Although this effect was found in athymic mice that lack T lymphocytes, it is still possible that the enhanced efficacy is due to preservation of other immune cell types such as natural killer cells. |
Synonyms | G1T28 hydrochloride |
Molecular Weight | 519.47 |
Formula | C24H32Cl2N8O |
CAS No. | 1977495-97-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
You can also refer to dose conversion for different animals. More
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Trilaciclib hydrochloride 1977495-97-8 Cell Cycle/Checkpoint CDK Inhibitor Cyclin dependent kinase inhibit Trilaciclib Hydrochloride Trilaciclib G1T28 Hydrochloride G1T28 G1T28 hydrochloride inhibitor