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Triglycidyl isocyanurate

Catalog No. T22443   CAS 2451-62-9
Synonyms: Tris(2,3-epoxypropyl) Isocyanurate, Teroxirone, TGIC, TGI

Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research[1][2]. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Triglycidyl isocyanurate Chemical Structure
Triglycidyl isocyanurate, CAS 2451-62-9
Pack Size Availability Price/USD Quantity
500 mg In stock $ 40.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 95.23%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research[1][2]. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
In vitro Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1].
In vivo Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors without effect on weight in nude mice[2].
Cell Research Triglycidyl isocyanurate (0-30 μM; 48?hours) Inhibited tumor cells(A549, H460 and H1299 cells)growth in soft agar. Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres.
Animal Research Triglycidyl isocyanurate (Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days)Inhibited the growth of xenograft tumors[2].
Synonyms Tris(2,3-epoxypropyl) Isocyanurate, Teroxirone, TGIC, TGI
Molecular Weight 297.26
Formula C12H15N3O6
CAS No. 2451-62-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49 mg/ml (164.83 mM)

TargetMolReferences and Literature

1. Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143 2. Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Ubiquitination Compound Library Pyroptosis Compound Library Anti-Cancer Metabolism Compound Library Anti-Lung Cancer Compound Library Human Metabolite Library NO PAINS Compound Library Anti-Pancreatic Cancer Compound Library Apoptosis Compound Library PPI Inhibitor Library

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Keywords

Triglycidyl isocyanurate 2451-62-9 Apoptosis Tris(2,3-epoxypropyl) Isocyanurate hepatocellular Hep3B Teroxirone Inhibitor TGIC HCC tumor inhibit anticancer agent liver cancer carcinoma NSCLC HepG2 MDM-2/p53 TGI inhibitor

 

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