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Triflusal

Catalog No. T0705 CAS 322-79-2

Synonyms: UR1501

Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.

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Triflusal, CAS 322-79-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 118.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 328.00
200 mg	In stock	$ 493.00
500 mg	In stock	$ 789.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.61%

Purity: 93.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
Targets&IC50	COX-2:160 μM (IC50, in human blood), COX-2:280 μM (IC50)
In vitro	The main Triflusal metabolite, HTB, preserves 6-keto-PGF1α synthesis in porcine aortic endothelial cells (PAEC) cells without a significant decline for up to 24 h even at the higher concentration. [1] Triflusal at 10 mM, 100 mM and 1 M decreases LDH efflux in rat brain slices after anoxia/reoxygenation by 24%, 35% and 49% respectively. Triflusal also reduces inducible NO synthase activity by 18%, 21% and 30%. [2]
In vivo	Triflusal (10 mg/kg i.v.) reduces platelet deposition on subendothelium-induced primary thrombus by about 68% in rabbits. Triflusal (10 mg/kg i.v.) reduces platelet deposition on a fresh thrombus formed over tunica media by about 48% in rabbits. Triflusal (40 mg/kg p.o.) reduces platelet deposition on a primary thrombus triggered by subendothelium and tunica media by 53% in rabbits. Triflusal (40 mg/kg p.o.) significantly reduces Cox-2 mRNA levels and protein levels without influence Cox-1 mRNA levels on the vascular wall in rabbits. [1] Triflusal (600 mg/day for 5 days) results in an increase in NO production by neutrophils and an increase in endothelial nitric oxide synthase (eNOS) protein expression in neutrophils in healthy volunteers. [3] Triflusal (300 mg, twice-daily orally) shows a more important increase in total walking distance and in pain-free walking distance over the basal values than those treated with placebo, together with an improvement of the symptomatology correlated with claudication in patients with chronic peripheral arteriopathy. Triflusal (300 mg, twice-daily orally) shows an increase in the peak-flow recorded through strain-gauge plethysmography in patients with chronic peripheral arteriopathy. [4] Triflusal (30 mg/kg) strongly decreases iNOS immunolabeling at both survival times analyzed, attenuating iNOS immunoreactivity in astroglial cells and infiltrated neutrophils in rats. Triflusal (30 mg/kg) decreases neuronal and microglial COX-2 expression at 10 and 24 hours after lesion and microglial and astroglial expression of IL-1beta and TNF-alpha at 24 hours after lesion in rats. [5]

Synonyms	UR1501
Molecular Weight	248.16
Formula	C10H7F3O4
CAS No.	322-79-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 47 mg/mL (189.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 47 mg/mL (189.4 mM)

References and Literature

1. Duran X, et al. J Thromb Haemost, 2008, 6(8), 1385-1392. 2. González-Correa JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jan;371(1):81-8. 3. De Miguel LS, et al. Eur J Clin Invest, 2000, 30(9), 811-817. 4. Auteri A, et al. Int J Clin Pharmacol Res, 1995, 15(2), 57-63. 5. Acarin L, et al. Stroke, 2002, 33(10), 2499-2505.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Highly Selective Inhibitor Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Breast Cancer Compound Library Drug-Fragment Library Anti-Aging Compound Library Anti-Metabolism Disease Compound Library

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Keywords

Triflusal 322-79-2 DNA Damage/DNA Repair Immunology/Inflammation Metabolism Neuroscience COX PPAR PDE inhibit Inhibitor Cyclooxygenase UR1501 UR 1501 UR-1501 inhibitor

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