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Metabolism Retinoid Receptor Tretinoin

Tretinoin

Catalog No. T1051   CAS 302-79-4
Synonyms: all-trans-Retinoic acid, Vitamin A acid, ATRA, Retinoic acid

Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. Tretinoin is a naturally-occurring acid of retinol. The oral form of tretinoin has teratogenic and embryotoxic properties.

Tretinoin, CAS 302-79-4
Pack Size Availability Price/USD Quantity
10 mg In stock 20.00
25 mg In stock 32.00
50 mg In stock 40.00
100 mg In stock 50.00
200 mg In stock 60.00
500 mg In stock 75.00
1 g In stock 90.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 99.52%
Purity 98.00%
Purity 97.21%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. Tretinoin is a naturally-occurring acid of retinol. The oral form of tretinoin has teratogenic and embryotoxic properties.
Targets&IC50 RAR
Cell Research
Retinoic acid is dissolved in DMSO and stored, and then diluted with appropriate medium before use[3]. P19 cell are induced to undergo neuronal differentiation according to established procedures. Briefly, cells are cultured on 1% agarose-coated 10 cm dishes at 3×10 5 cells/mL in α-minimal essential medium supplemented with 10% FBS. Differentiation is induced by addition of Retinoic acid (1 μM) and medium containing Retinoic acid replaced 2 days later. On day 4, cell aggregates are collected by centrifugation, separated to single cells by trypsin/EDTA treatment, replated onto poly-L-lysine-coated plates, and cultured in α-minimal essential medium supplemented with 10% FBS. On day 6, medium is replaced with neurobasal medium containing B27 supplement and 2 mM GlutaMAX. Medium is replaced every 2 days for an additional week[3].
Synonyms all-trans-Retinoic acid , Vitamin A acid , ATRA , Retinoic acid
Purity 99.52%
Molecular Weight 300.44
Formula C20H28O2
CAS No. 302-79-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 56 mg/mL (186.4 mM)

Ethanol: 6 mg/mL (19.97 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Manzano VM, et al. J Pharmacol Exp Ther, 1999, 289(1), 123-132. 2. Uchida G, et al. Exp Dermatol, 2003, 12 ,Suppl 2, 35-42. 3. Schwartz E, et al. J Invest Dermatol, 1994, 102(2), 241-246. 4. Solis RR, et al. Dermatol Surg, 2002, 28(1), 83-6, discussion 86-87. 5. Muehlberger T, et al. J Am Acad Dermatol, 2005, 52(4), 583-588. 6. Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11(4):e0153556. 7. Wan X Q, Cai J Y, Zhu Y, et al. SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells[J]. International journal of molecular medicine. 2019 Jan;43(1):371-381. 8. Wei Z, Li T, Sun Y, et al. Daturataturin A, a withanolide in Datura metel L., induces HaCaT autophagy through the PI3K‐Akt‐mTOR signaling pathway[J] . Phytotherapy Research. 2021 9. Yanxing Wang, Xiaodong Dou, Lan Jiang, Hongwei Jin, Lihe Zhang, Liangren Zhang, and Zhenming Liu. Discovery of novel glycogen synthase kinase-3α inhibitors: Structurebased virtual screening, preliminary SAR and biological evaluation for treatment of acute myeloid leukemia [J]. European Journal of Medicinal Chemistry. 2019 Jun 1;171:221-234. 10. Qiu Y, Sun Y, Xu D, et al. Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue[J]. EBioMedicine. 2018, 37: 344-355.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Stem cell Differentiation Compound Library Apoptosis Compound Library Autophagy Compound Library Human Endogenous Metabolite Compound Library FDA-approved Drug Library Immunology/Inflammation Compound Library DNA Damage & Repair Compound Library Bioactive Lipid Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Killers Collection Anti-cancer Metabolism Compound Library Preclinical Compound Library NF-κB Signaling Compound Library CNS-Penetrant Compound Library Nuclear-receptor Inhibitors Library Promoting Cancer Cell Differentiation Compound Library Anti-aging Compound Library Hematonosis Compound Library Antitumor Natural Products Library Anti-cancer Active Compound library Anti-cancer Drug library Drug Repurposing Library Terpene natural compound library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library Lipid Metabolism Compound Library

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