Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 222.00 | |
5 mg | In stock | $ 563.00 | |
10 mg | In stock | $ 812.00 | |
25 mg | In stock | $ 1,230.00 | |
50 mg | In stock | $ 1,670.00 | |
100 mg | In stock | $ 2,260.00 | |
500 mg | In stock | $ 4,530.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 618.00 |
Description | TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use. |
Targets&IC50 | PDE5:0.62 nM |
Molecular Weight | 441.57 |
Formula | C24H35N5O3 |
CAS No. | 1229018-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (51.0 mM), ultrasonic and warming and heat to 60°C
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TPN171 1229018-87-4 Metabolism PDE TPN 171 TPN-171 inhibitor inhibit