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Succinyl phosphonate trisodium salt

Catalog No. T13019 CAS 864167-45-3

Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)

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Succinyl phosphonate trisodium salt Chemical Structure

Succinyl phosphonate trisodium salt, CAS 864167-45-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 138.00
2 mg	In stock	$ 198.00
5 mg	In stock	$ 343.00
10 mg	In stock	$ 490.00
25 mg	In stock	$ 783.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,480.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)

Molecular Weight	248.01
Formula	C4H4Na3O6P
CAS No.	864167-45-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 125 mg/mL (504.01 mM), Sonification is recommended.

References and Literature

1. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70. 2. Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21. 3. Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6. 4. Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NF-κB Signaling Compound Library Immunology/Inflammation Compound Library NO PAINS Compound Library Metabolism Compound Library Antioxidant Compound Library Anti-Parkinson's Disease Compound Library Bioactive Compound Library Mitochondria-Targeted Compound Library Anti-Breast Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Succinyl phosphonate trisodium salt 864167-45-3 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species Dehydrogenase Endogenous Metabolite inhibit Succinyl phosphonate Inhibitor Succinyl phosphonate trisodium inhibitor

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