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Stylopine hydrochloride

Catalog No. T5807 CAS 96087-21-7

Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.

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Stylopine hydrochloride Chemical Structure

Stylopine hydrochloride, CAS 96087-21-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 72.00
5 mg	In stock	$ 155.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 418.00
50 mg	In stock	$ 596.00
100 mg	In stock	$ 863.00

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Purity: 99.34%

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Description	Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
In vitro	Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries.?Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.?The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner.?Suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions.?These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus.
Source	Natural Products > Papaveraceae > Chelidonium

Molecular Weight	359.8
Formula	C19H18ClNO4
CAS No.	96087-21-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (13.89 mM)

References and Literature

1. Jang S , Kim B H , Lee W Y , et al. Stylopine fromChelidonium majusinhibits LPS-Induced inflammatory mediators in RAW 264.7 cells[J]. Archives of Pharmacal Research (Seoul), 2004, 27(9):923-929.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Anti-Parasitic Compound Library Natural Product Library Anti-Pancreatic Cancer Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Neuronal Signaling Compound Library Anti-Fibrosis Compound Library Traditional Mongolian Medicine Compound Library Traditional Chinese Medicine Monomer Library Pyroptosis Compound Library

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Keywords

Stylopine hydrochloride 96087-21-7 Immunology/Inflammation Neuroscience COX NOS alkaloid (±)-Stylopine Corydalis Inhibitor Tetrahydrocoptisine anti-parasitic inhibit Stylopine Hydrochloride inhibitor

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