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Senexin B

Catalog No. T8430   CAS 1449228-40-3

Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).

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Senexin B Chemical Structure
Senexin B, CAS 1449228-40-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 135.00
5 mg In stock $ 276.00
10 mg In stock $ 413.00
25 mg In stock $ 689.00
50 mg In stock $ 979.00
100 mg In stock $ 1,320.00
1 mL * 10 mM (in DMSO) In stock $ 285.00
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Purity: 99.63%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).
Targets&IC50 CDK19:80 nM (Kd) , CDK8:140 nM (Kd)
In vitro Senexin B inhibits CDK8/19 in low nanomolar range[1]
In vivo In a spleen-to-liver colon cancer metastasis model of syngeneic mouse CT26 tumors, Senexin B treatment of mice had the same effect as CDK8 knockdown in tumor cells: suppression of metastatic growth in the liver without a significant effect on primary tumor growth in the spleen[1].
Molecular Weight 450.53
Formula C27H26N6O
CAS No. 1449228-40-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6 mg/mL (13.32 mM), sonification/heating is recommended.

TargetMolReferences and Literature

1. Porter D, et al. Abstract PR08: Targeting tumor microenvironment with selective small-molecule inhibitors of CDK8/19. Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr PR08. doi:10.1158/1538-7445.CHTME14-PR08 2. Chen M , Li J , Liang J , et al. Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition[J]. 2019.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Preclinical Compound Library Inhibitor Library NO PAINS Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compound Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Cell Cycle Compound Library

Related Products

Related compounds with same targets
PF-562271 hydrochloride CDK4/6-IN-17 QR-6401 TP-353 Simurosertib CDK4-IN-2 THZ1 CDK9-IN-23

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Keywords

Senexin B 1449228-40-3 Cell Cycle/Checkpoint CDK inhibitor inhibit

 

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