Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 276.00 | |
10 mg | In stock | $ 413.00 | |
25 mg | In stock | $ 689.00 | |
50 mg | In stock | $ 979.00 | |
100 mg | In stock | $ 1,320.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 285.00 |
Description | Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM). |
Targets&IC50 | CDK19:80 nM (Kd) , CDK8:140 nM (Kd) |
In vitro | Senexin B inhibits CDK8/19 in low nanomolar range[1] |
In vivo | In a spleen-to-liver colon cancer metastasis model of syngeneic mouse CT26 tumors, Senexin B treatment of mice had the same effect as CDK8 knockdown in tumor cells: suppression of metastatic growth in the liver without a significant effect on primary tumor growth in the spleen[1]. |
Molecular Weight | 450.53 |
Formula | C27H26N6O |
CAS No. | 1449228-40-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (13.32 mM), sonification/heating is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Senexin B 1449228-40-3 Cell Cycle/Checkpoint CDK inhibitor inhibit