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SQ-31765

Catalog No. T12993 CAS 138383-07-0

SQ-31765 is a blocker of benzazepine calcium channel.

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SQ-31765, CAS 138383-07-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

SQ-31765 is a blocker of benzazepine calcium channel.

In vivo

SQ-31765 (SQ 31,765) effectively mitigates the severity of ischemia independent of myocardial blood flow or hemodynamic changes. In a study, anesthetized dogs were administered either saline (n=6), SQ-31765 (n=6; 0.2 mg/kg), or SQ 32,189 (n=6; 0.2 mg/kg) intravenously 10 minutes prior to inducing ischemia. The research focused on the compound's impact on pacing-induced ST-segment elevation and myocardial blood flow during left anterior descending coronary artery stenosis. SQ-31765 significantly lowered ST-segment elevation (P<0.05) at 10, 40, and 70 minutes post-infusion, showcasing a notable reduction (5.9±1.4 mV at 70 minutes) compared to the saline group (12.0±1.4 mV at 70 minutes). All test groups exhibited a marked decrease in subendocardial flow due to left anterior descending coronary artery stenosis during atrial pacing prior to drug administration, underscoring SQ-31765's protective effects against pacing-induced myocardial injury.

Molecular Weight	464.48
Formula	C24H27F3N2O4
CAS No.	138383-07-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Grover GJ, et al. Anti-ischemic and vasorelaxant effects of the new benzazepine calcium channel blocker SQ 31,765. J Pharmacol Exp Ther. 1989 Dec;251(3):1020-5.

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Keywords

SQ-31765 138383-07-0 Membrane transporter/Ion channel Metabolism Calcium Channel SQ31765 SQ 31765 inhibitor inhibit

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