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Chromatin/Epigenetic Pim SMI-4a

SMI-4a

Catalog No. T4215   CAS 327033-36-3
Synonyms: TCS-PIM-1-4a
Purity 99.89% Datasheet

TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).

SMI-4a, CAS 327033-36-3
Pack Size Availability Price/USD Quantity
5 mg In stock 58.00
10 mg In stock 78.00
25 mg In stock 140.00
50 mg In stock 259.00
100 mg In stock 467.00
200 mg In stock 840.00
1 mL * 10 mM (in DMSO) In stock 64.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
Targets&IC50 Pim 1 :ic50 24nM,   Pim 2 :ic50 100nM,   Pim 1/2,  

Description

TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).

Targets&IC50

Pim 1 :ic50 24nM

Pim 2 :ic50 100nM

Pim 1/2

Synonyms TCS-PIM-1-4a
Purity 99.89%
Appearance solid
Molecular Weight 273.23
Formula C11H6F3NO2S
CAS No. 327033-36-3

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Lin YW, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33. 2. Beharry Z, et al. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011;108(2):528-33. 3. Benoit SR, Ji M, Fleming R,et al . Predictors of dropouts from a San Diego diabetes program: a case control study. Prev Chronic Dis. 2004:1(4):A10. 4. Xia Z, et al. Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases. J. Med. Chem., 2009, 52 (1), pp 74-86

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Anti-cancer Compound Library Clinical Compound Library Epigenetics Compound Library Kinase Inhibitor Library Anti-cancer Clinical Compound Library Fluorochemical Library Preclinical Compound Library JAK STAT Compound Library

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TCS PIM-1 1 AZD1208 SMI-4a SGI-1776 free base SMI-16a SMI-4a CX-6258 HCl XL413 hydrochloride

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