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MAPK Raf SB590885

SB590885

Catalog No. T2295   CAS 405554-55-4

SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay). The selectivity of SB590885 for B-Raf is 11-fold greater over c-Raf, no acts to other human kinases.

SB590885, CAS 405554-55-4
Pack Size Availability Price/USD Quantity
5 mg In stock 90.00
10 mg In stock 155.00
25 mg In stock 310.00
50 mg In stock 598.00
100 mg In stock 998.00
1 mL * 10 mM (in DMSO) In stock 140.00
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Purity 95.43%
Purity 98.00%
Purity 98.48%
Biological Description
Chemical Properties
Storage & Solubility Information
Preparing Solutions
Description SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay). The selectivity of SB590885 for B-Raf is 11-fold greater over c-Raf, no acts to other human kinases.
Targets&IC50 B-Raf
Cell Research
Cells are treated with increasing concentrations of SB590885 and incubated for 72 hours. Viable cells are quantified using CellTiter-Glo reagent and luminescence detection on a Victor 2V plate reader. Cells are prepared for cell cycle analysis on a Becton Dickinson FACScan. Data is acquired and analyzed using CellQuest v3.3 software.(Only for Reference)
Cell lines: Colo205, HT29, A375P, SKMEL28, and MALME-3M
Molecular Weight 453.54
Formula C27H27N5O2
CAS No. 405554-55-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 25mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0: 30 mg/mL

Citations

References and Literature
1. King AJ, et al. Cancer Res, 2006, 66(23), 11100-11105. 2. Takle AK, et al. Bioorg Med Chem Lett, 2006, 16(2), 378-381. 3. Smalley KS, et al. Mol Cancer Ther, 2008, 7(9), 2876-2883.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Apoptosis Compound Library Autophagy Compound Library Neuronal Signaling Compound Library MAPK Inhibitor Library Tyrosine kinase inhibitor library Kinase Inhibitor Library Anti-cancer Metabolism Compound Library Preclinical Compound Library CNS-Penetrant Compound Library Anti-obesity Compound Library Anti-cancer Active Compound library Target-Focused Phenotypic Screening Library HIF-1 Signaling Pathway Compound Library Anti-Pancreatic Cancer Compound Library Glutamine Metabolism Compound Library

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.