Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.
Description | SB-399885 hydrochloride is an antagonist of 5-HT6 receptor. |
In vivo | SB-399885 hydrochloride, administered at a dose of 10 mg/kg, significantly enhances wakefulness (W) (F(3,15)=3.32, P<0.05) and decreases both slow wave sleep (SWS) and rapid-eye-movement sleep (REMS), as well as reducing the number of REM periods (F(3,15)=4.0, P<0.01; F(3,15)=3.14, P<0.05 and F(3,15)=2.62, P<0.05, respectively) compared to the control vehicle. Further analysis on 2-hour intervals revealed that this dose increased W (F(3,15)=5.48, P<0.01) and diminished SWS and REMS during the initial 2-hour period (F(3,15)=5.42, P<0.01 and F(3,15)= 4.05, P<0.01, respectively). Additionally, doses of 5 and 10 mg/kg were found to increase light sleep across the first and second 2-hour recording periods (F(3,15)=3.46,P<0.01 and F(3,15)= 3.65, P<0.01; and F(3,15)=3.23, P<0.05 and F(3,15)=3.08, P<0.05, respectively). The 10 mg/kg dose also notably prolonged REMS latency (F(3,15)=3.60, P<0.01) and decreased the number of REM periods within the first two hours of recording (F(3,15)=3.88, P<0.01). |
Molecular Weight | 482.81 |
Formula | C18H22Cl3N3O4S |
CAS No. | 402713-81-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (258.90 mM), Sonification and heating are recommended.
You can also refer to dose conversion for different animals. More
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