Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro 10-5824 dihydrochloride is a selective agonist of dopamine D4 receptor partial, (Ki of 5.2 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 162.00 | |
50 mg | In stock | $ 238.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | Ro 10-5824 dihydrochloride is a selective agonist of dopamine D4 receptor partial, (Ki of 5.2 nM). |
Targets&IC50 | D4 receptor:5.2 nM (ki) |
In vitro | RO-10-5824 shows high affinity binding(Ki=5.2±0.9 nM (n=3)), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding (EC50 : 205±67 nM) (n=7) and maximal induction at 36±4% above basal level[2]. |
In vivo | The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice[2]. |
Molecular Weight | 353.29 |
Formula | C17H22Cl2N4 |
CAS No. | 189744-94-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 60 mg/mL (169.83 mM)
DMSO: 8.33 mg/mL (23.58 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Ro 10-5824 dihydrochloride 189744-94-3 GPCR/G Protein Neuroscience Dopamine Receptor Inhibitor inhibit Ro 105824 dihydrochloride Ro 10-5824 Dihydrochloride Ro 10-5824 Ro 10 5824 dihydrochloride inhibitor