Powder: -20°C for 3 years
In solvent: -80°C for 2 years
BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
Description | BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM. |
Targets&IC50 | CGRP Receptor:0.14 nM |
In vitro | BMS-927711 is a full, competitive CGRP receptor antagonist with IC50 of 0.14±0.01 nM. |
In vivo | The ratios of the mean AUC (0-24 h) values for BMS-927711 (60, 100, and 300 mg/kg) in the DBS matrix, compare with plasma, are 0.5-0.6 across all doses in rats. Results from this study suggest a strong correlation of BMS-927711 concentrations between rat plasma and rat blood (DBS).BMS-927711 has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical properties, and shows dose-dependent activity in a primate model of CGRP-induced facial blood flow |
Synonyms | BMS 927711, BMS927711, BHV-3000, BMS-927711 |
Molecular Weight | 534.568 |
Formula | C28H28F2N6O3 |
CAS No. | 1289023-67-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10 mg/mL
Ethanol: 10 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Rimegepant 1289023-67-1 离子通道 CGRP Receptor Inhibitor BMS 927711 Calcitonin gene-related peptide receptor BMS-927711 inhibit BHV-3000 BMS927711 inhibitor