store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
QF0301B is a potent α1-adrenergic receptor antagonist with inhibitory effects on α2-adrenergic receptors, 5-HT2A and histamine H1 receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 700.00 | |
5 mg | In stock | $ 1,800.00 |
Description | QF0301B is a potent α1-adrenergic receptor antagonist with inhibitory effects on α2-adrenergic receptors, 5-HT2A and histamine H1 receptors. |
Targets&IC50 | Adrenoceptor: |
In vitro | QF0301B exhibits marked α1-adrenoceptor blocking activity in isolated rubbed rat aorta rings, with a pA2 value of 9.00±0.12. In electrically stimulated rat vas deferens, QF0301B reverses and competitively antagonizes the inhibitory action produced by clonidine. Additionally, it inhibits the force and rate of contraction in rat isolated atria (pA2=5.91±0.43), competitively antagonizes the contractile effect of 5-HT in rat aorta (pA2=6.75±0.06) and in rat stomach fundus (pA2=7.13±0.48), as well as the contractions induced by histamine in isolated guinea pig longitudinal ileal muscle (pA2=7.40±0.40). QF0301B shows noncompetitive low action in 5-HT3, muscarinic, and nicotinic receptors, as well as Ca2+ antagonist[1]. |
In vivo | QF0301B (0.1-0.2 mg/kg iv) induces a pronounced and prolonged fall in mean arterial blood pressure accompanied by bradycardia. It does not significantly modify the cardiovascular effects of either 5-hydroxytryptamine (serotonin, 5-HT, 75 mg/kg iv) or the selective α2-adrenoceptor agonist B-HT 920 (0.2 mg/kg iv). However, QF0301B markedly inhibits the hypertensive effect of noradrenaline (5 mg/kg iv), a nonselective α-adrenergic receptor agonist[1]. |
Molecular Weight | 364.48 |
Formula | C23H28N2O2 |
CAS No. | 149247-12-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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QF0301B 149247-12-1 GPCR/G Protein Neuroscience Adrenergic Receptor 5-HT Receptor QF-0301B inhibitor inhibit