Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 31.00 | |
25 mg | In stock | $ 48.00 | |
50 mg | In stock | $ 72.00 | |
100 mg | In stock | $ 105.00 | |
200 mg | In stock | $ 155.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). |
In vitro | Pyributicarb was found to increase the CYP3A4 reporter activity at 0.1 to 1 microM more strongly than typical CYP3A4 inducer rifampicin.?Expression of hPXR-siRNA clearly diminished the pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreased the endogenous CYP3A4 mRNA levels in HepG2 cells.?Pyributicarb caused enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus[1]. |
Synonyms | TSH-888 |
Molecular Weight | 330.44 |
Formula | C18H22N2O2S |
CAS No. | 88678-67-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (302.63 mM)
You can also refer to dose conversion for different animals. More
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Pyributicarb 88678-67-5 Metabolism P450 Cytochrome P450 TSH888 CYPs Inhibitor TSH-888 TSH 888 inhibit inhibitor