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Procyanidin A2

Catalog No. TN1132 CAS 41743-41-3

Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 diabetes activities. Procyanidin A2 demonstrates liver cell regenerative activity in scratch wound healing assays and alcohol-induced liver cell injury in vitro.

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Procyanidin A2, CAS 41743-41-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 369.00
25 mg	In stock	$ 615.00
50 mg	In stock	$ 869.00
100 mg	In stock	$ 1,170.00
1 mL * 10 mM (in DMSO)	In stock	$ 313.00

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Purity: 98.78%

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Description	Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 diabetes activities. Procyanidin A2 demonstrates liver cell regenerative activity in scratch wound healing assays and alcohol-induced liver cell injury in vitro.
In vitro	Here we evaluated Procyanidin A2 as a means of modulating CCL26 production and investigated interactions with the known inflammation modulator, Interferon γ (IFNγ). We used the human lung epithelial cell line A549 and optimized the conditions for inducing CCL26. Cells were exposed to a range of Procyanidin A2 or IFNγ concentrations for varied lengths of time prior to an inflammatory insult of interleukin-4 (IL-4) for 24 h. An enzyme-linked immunosorbent assay was used to measure CCL26 production. Exposing cells to 5 μM Procyanidin A2 (prior to IL-4) reduced CCL26 production by 35% compared with control. Greatest inhibition by Procyanidin A2 was seen with a 2 h exposure prior to IL-4, whereas IFNγ inhibition was greatest at 24 h. Concomitant incubation of Procyanidin A2 and IFNγ did not extend the inhibitory efficacy of Procyanidin A2[1]
Source	Natural Products > Arecaceae > Daemonorops

Molecular Weight	576.5
Formula	C30H24O12
CAS No.	41743-41-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (173.46 mM), Sonication is recommended.

References and Literature

1. Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells.Int J Mol Sci. 2016 Nov 12;17(11). pii: E1888.

Related compound libraries

This product is contained In the following compound libraries：

NF-κB Signaling Compound Library Tibetan medicine Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Natural Product Library Traditional Mongolian Medicine Compound Library Anti-Cardiovascular Disease Compound Library Oxidation-Reduction Compound Library Cytokine Inhibitor Library Bioactive Compounds Library Max Chinese Pharmacopoeia Natural Product Library

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Keywords

Procyanidin A2 41743-41-3 Apoptosis Immunology/Inflammation Metabolism Microbiology/Virology transporter TNF IL Receptor Antibacterial Procyanidin A 2 Bacterial Procyanidin A-2 Inhibitor inhibit inhibitor

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