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Prochlorperazine Maleate

Catalog No. T0385 CAS 84-02-6

Synonyms: Prochlorperazin, Capazine, Prochlorperazine dimaleate salt, Stemetil, Compazine

Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.

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Prochlorperazine Maleate Chemical Structure

Prochlorperazine Maleate, CAS 84-02-6

Pack Size	Availability	Price/USD
25 mg	In stock	$ 38.00
50 mg	In stock	$ 50.00
100 mg	In stock	$ 65.00
200 mg	In stock	$ 118.00
500 mg	In stock	$ 222.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.
In vitro	Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2].
In vivo	Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1].
Cell Research	Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.(Only for Reference)

Synonyms	Prochlorperazin, Capazine, Prochlorperazine dimaleate salt, Stemetil, Compazine
Molecular Weight	606.09
Formula	C28H32ClN3O8S
CAS No.	84-02-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 2 mg/mL (3.3 mM), Heating is recommended.

DMSO: 15.2 mg/mL (25 mM)

References and Literature

1. Ghelardini C, et al. Pharmacol Res. 20014, 50(3):351-358. 2. Huang L, et al. PLoS One. 2011, 6(7):e22274. 3. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation[J]. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

Citations

1. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library GPCR Compound Library Neurotransmitter Receptor Compound Library Endocrinology-Hormone Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Parkinson's Disease Compound Library

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Keywords

Prochlorperazine Maleate 84-02-6 GPCR/G Protein Neuroscience Dopamine Receptor Prochlorperazin Prochlorperazine Capazine Prochlorperazine Dimaleate Prochlorperazine dimaleate salt Stemetil Compazine inhibitor inhibit

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