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Prasugrel (Maleic acid)

Catalog No. T16572   CAS 389574-20-3
Synonyms: PCR 4099 (Maleic acid)

Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist and inhibits ADP-induced platelet aggregation. Prasugrel Maleic acid is a thienopyridine and prodrug. Prasugrel Maleic acid also inhibits platelet function.

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Prasugrel (Maleic acid) Chemical Structure
Prasugrel (Maleic acid), CAS 389574-20-3
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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Biological Description
Chemical Properties
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Description Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist and inhibits ADP-induced platelet aggregation. Prasugrel Maleic acid is a thienopyridine and prodrug. Prasugrel Maleic acid also inhibits platelet function.
In vitro Prasugrel hydrochloride is an inactive prodrug that requires metabolic processing in vivo to generate the active antiplatelet metabolite. Prasugrel Maleic acid is rapidly absorbed from the gut. Prasugrel Maleic acid active metabolite inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) (IC50: 1.8 μM), in rat platelets. Prasugrel Maleic acid acts faster and is significantly more effective than Clopidogrel in vivo. After oral administration of standard-loading doses of 60 mg, maximum plasma levels of the active metabolite are achieved within 1 h, effective, maximum inhibition of platelet aggregation at 1-2 h[1][2].
Synonyms PCR 4099 (Maleic acid)
Molecular Weight 489.51
Formula C24H24FNO7S
CAS No. 389574-20-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Wijeyeratne YD, et al. Anti-platelet therapy: ADP receptor antagonists. Br J Clin Pharmacol. 2011 Oct;72(4):647-57. 2. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51.

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Keywords

Prasugrel (Maleic acid) 389574-20-3 PCR4099 PCR 4099 Maleic acid Prasugrel PCR-4099 PCR 4099 (Maleic acid) inhibitor inhibit

 

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