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Platycodin D3

Catalog No. TN2089   CAS 67884-03-1

Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway mucin; it can significantly enhance mitogen- and OVA-induced splenocyte proliferation in the OVA-immunized mice. Platycodin D3 also exerts anti-Hepatitis C virus (HCV) activity.

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Platycodin D3 Chemical Structure
Platycodin D3, CAS 67884-03-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 117.00
5 mg In stock $ 235.00
10 mg In stock $ 372.00
1 mL * 10 mM (in DMSO) In stock $ 598.00
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Purity: 98.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway mucin; it can significantly enhance mitogen- and OVA-induced splenocyte proliferation in the OVA-immunized mice. Platycodin D3 also exerts anti-Hepatitis C virus (HCV) activity.
In vitro The aim of this study was to evaluate the functional effects of triterpenoid saponins contained in the root extract of Platycodon grandiflorum (PG) on viral enzyme activities and replication in both HCV replicon cells and cell culture grown HCV- (HCVcc-) infected cells. Inhibitory activities of triterpenoid saponins from PG were verified by NS5B RNA-dependent RNA polymerase assay and were further confirmed in the context of HCV replication. Six triterpenoid saponins (platycodin D, platycodin D2, Platycodin D3, deapioplatycodin D, deapioplatycodin D2, and platyconic acid A), PG saponin mixture (PGSM), were identified as active components exerting anti-HCV activity. Importantly, PGSM exerted synergistic anti-HCV activity in combination with either interferon- α± or NS5A inhibitors.
Source
Molecular Weight 1387.46
Formula C63H102O33
CAS No. 67884-03-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (43.24 mM)

TargetMolReferences and Literature

1. Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication.Evid Based Complement Alternat Med. 2013;2013:560417.

TargetMolCitations

1. Lee S J, Kim H W, Lee S, et al. Characterization of Saponins from Various Parts of Platycodon grandiflorum Using UPLC-QToF/MS. Molecules. 2022, 27(1): 107.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Bioactive Compound Library Natural Product Library for HTS Anti-Cancer Compound Library Anti-Viral Compound Library Transcription Factor-Targeted Compound Library Inhibitor Library Anti-Pancreatic Cancer Compound Library Terpene Natural Product Library Traditional Chinese Medicine Monomer Library

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Keywords

Platycodin D3 67884-03-1 Microbiology/Virology NF-Κb Proteases/Proteasome HCV Protease NF-κB inhibit HCV Platycodin D 3 Hepatitis C virus Inhibitor Platycodin D-3 inhibitor

 

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