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Pilocarpine nitrate

Catalog No. T1231   CAS 148-72-1
Synonyms: Pilagan, Pilofrin

Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.

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Pilocarpine nitrate Chemical Structure
Pilocarpine nitrate, CAS 148-72-1
Pack Size Availability Price/USD Quantity
100 mg In stock $ 41.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.48%
Purity: 99.48%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Source
Synonyms Pilagan, Pilofrin
Molecular Weight 271.27
Formula C11H16N2O2·HNO3
CAS No. 148-72-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (101.37 mM)

TargetMolReferences and Literature

1. Sykes DA, et al. Mol Pharmacol. 2009 Sep;76(3):543-51. 2. Wang, Xingqi, et al. A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for Efficient Ophthalmic Delivery of Pilocarpine Nitrate [J]. AAPS PharmSciTech. 2019 Jan 2;20(1):32. 4. Xingqi Wang, Yong Zhang, Jie Huang, Mengqiu Xia, Liu Liu, Chunling Tian, Rongfeng Hu, Shuangying Gui, and Xiaoqin Chu. Self-assembled hexagonal liquid crystalline gels as novel ocular formulation with enhanced topical delivery of pilocarpine nitrate [J]. International Journal of Pharmaceutics. 2019 May 1;562:31-41.

TargetMolCitations

1. Xingqi W, Yong Z, Xing L, et al. Cubic and hexagonal liquid crystal gels for ocular delivery with enhanced effect of pilocarpine nitrate on anti-glaucoma treatment. Drug Delivery. 2019 2. Wang X, Zhang Y, Huang J, et al. A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for Efficient Ophthalmic Delivery of Pilocarpine Nitrate. AAPS PharmSciTech. 2019, 20(1): 1-14 3. Lin H, Yang W Q, Ye Z, et al. Identification of Potent Caspase-8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen-based Light-up Probe. ChemBioChem. 2019, 20(10): 1292-1296

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Natural Product Library for HTS Antiparasitic Natural Product Library Orally Active Compound Library Natural Product Library Anti-Alzheimer's Disease Compound Library Anti-Parkinson's Disease Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library

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Keywords

Pilocarpine nitrate 148-72-1 Neuroscience AChR Pilocarpine Inhibitor inhibit Pilocarpine Nitrate Pilagan Pilofrin mAChR Muscarinic acetylcholine receptor inhibitor

 

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