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PHA767491 HCl

Catalog No. T6940    CAS 942425-68-5    Synonyms: CAY-10572 hydrochloride, PHA-767491 hydrochloride, PHA-767491, CAY10572

PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1.

Pack Size Availability Price/USD Quantity
5 mg In stock 50.00
10 mg In stock 68.00
25 mg In stock 123.00
100 mg In stock 442.00
1 mL * 10 mM (in DMSO) In stock 50.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1.

Receptor:

Cdc7; Cdk1; Cdk2; Cdk9; GSK-3β;

Chemical Information:
Molecular Weight 213.24
Formula C12H11N3O
CAS Number 942425-68-5
Solubility

DMSO: 25 mg/mL (100 mM)

water: 25 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.