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Metabolism PDE Mardepodect

Mardepodect

Catalog No. T6042
Synonyms: PF-2545920,
Purity 99.00% Datasheet MSDS

PF-2545920, a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.

Mardepodect, CAS 1292799-56-4
Pack Size Availability Price/USD Quantity
1 mg In stock 62.00
2 mg In stock 111.00
5 mg In stock 225.00
10 mg In stock 310.00
25 mg In stock 506.00
50 mg In stock 818.00
1 mL * 10 mM (in DMSO) In stock 241.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PF-2545920, a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.
Targets&IC50 PDE10A :ic50 0.37nM,  
In vitro PF-2545920 shows excellent potency and specificity in PDE10A with IC50 of 1.26 nM.
Animal Research
Animal Model: Jugular vein-cannulated Sprague-Dawley rats

Description

PF-2545920, a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.

Targets&IC50

PDE10A :ic50 0.37nM

In Vitro

PF-2545920 shows excellent potency and specificity in PDE10A with IC50 of 1.26 nM.

In Vivo

在小鼠CAR模型中,PF-2545920(0.3-1 mg/kg)具有显著的治疗效果。在雄性CF-1小鼠体内,PF-2545920(0.3-5 mg/kg)剂量腹腔内给药,引起GluR1磷酸化水平显著增加。在CF-1 小鼠的纹状体中,PF-2545920(3 mg/kg)腹腔内给药,增加脑啡肽和P物质mRNA水平的增加。大鼠纹状体切片中,PF-2545920(1 μM)处理30分钟,GluR1S845在细胞表面的磷酸化水平显著增加2倍,而不改变细胞表面总的GluR1。

Animal Research

Animal Model: Jugular vein-cannulated Sprague-Dawley rats

Synonyms PF-2545920,
Purity 99.87%
Appearance solid
Molecular Weight 392.45
Formula C25H20N4O
CAS No. 1292799-56-4
SMILES data to be upload

Storage

Powder: -20°C, 3years; 4°C, 2 years

In solvent: -80°C, 6 months; -20°C, 1 month

Solubility Information

Ethanol: 69 mg/mL (175.8 mM)

DMSO: 72 mg/mL (183.5 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Grauer SM, et al. J Pharmacol Exp Ther, 2009, 331(2), 574-590. 2. Verhoest PR, et al. J Med Chem, 2009, 52(16), 5188-5196.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Neuronal Signaling Compound Library Bioactive Lipid Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets
Mirodenafil dihydrochloride Robustine Pomiferin Moracin M Kushenol K 3-O-Methylquercetin THPP-1 Enoximone

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

 

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