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Olmesartan Medoxomil

Catalog No. T1518 CAS 144689-63-4

Synonyms: CS 866, Benicar

Olmesartan Medoxomil (Benicar) is an angiotensin II type 1 receptor blocker that is used to manage hypertension.

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Olmesartan Medoxomil, CAS 144689-63-4

Pack Size	Availability	Price/USD
10 mg	In stock	$ 48.00
50 mg	In stock	$ 61.00
100 mg	In stock	$ 101.00
200 mg	In stock	$ 152.00
500 mg	In stock	$ 344.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.9%

Purity: 98.92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Olmesartan Medoxomil (Benicar) is an angiotensin II type 1 receptor blocker that is used to manage hypertension.
Targets&IC50	AT1 receptor:66.2 μM
In vitro	Olmesartan Medoxomil significantly reduces liver hydroxyproline content, the mRNA expression of collagen alpha1(I) and alpha-smooth muscle actin (alpha-SMA), and plasma levels of transforming growth factor-beta1 (TGF-beta1). [1] Olmesartan Medoxomil is a pro-drug containing an ester moiety that, after oral administration, is rapidly cleaved to release the active form Olmesartan (RNH-6270). Olmesartan is a highly potent, competitive and selective All AT1 receptor antagonist with almost no antagonistic activity on AT2 and AT4 receptors. [2]
In vivo	Olmesartan produces a rapid and long-lasting inhibition of All-induced pressor responses in conscious rats. Oralolmesartan medoxomil also inhibits All-pressor response but onset of the action is slower compared with intravenous administration. Olmesartan Medoxomil exhibits dose-dependent antihypertensive effects in several rat and dog models, with the most marked effects seen in high plasma renin models, when compared with normal or low renin types. Olmesartan medoxomil exhibits, beside antihypertensive effects, beneficial effects in animal models of various types of nephrosis and heart failure, and anti-atherogenic effects in hyperlipidaemic animals. [2] Olmesartan Medoxomil dose-dependently ameliorates the colonic histopathological and biochemical injuries in rats, an effect that is comparable or even better than that of the standard Sulfasalazine. [3] Olmesartan medoxomil significantly reduces the induction of hypoxic cor pulmonale not only on echocardiographical observations but also in brain natriuretic peptide (BNP) in chronic hypoxic rats, TGF-beta and endothelin gene expressions in molecular studies. [4]

Synonyms	CS 866, Benicar
Molecular Weight	558.59
Formula	C29H30N6O6
CAS No.	144689-63-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 82 mg/mL (146.8 mM)

References and Literature

1. Kurikawa N, et al. Br J Pharmacol,2003, 139(6), 1085-1094. 2. Koike H, et al. J Hypertens Suppl,2001,9(1), S3-14. 3. Nagib MM, et al. Toxicol Appl Pharmacol,2013, 271(1), 106-113. 4. Nakamoto T, et al. Eur J Pharmacol,2005, 528(1-3), 43-51. 6. Gu J, et al. Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis. Kidney Blood Press Res. 2016 Nov 21;41(6):848-864.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Metabolism Disease Compound Library FDA-Approved Drug Library Angiogenesis related Compound Library Orally Active Compound Library Anti-COVID-19 Compound Library Anti-Cardiovascular Disease Compound Library Bioactive Compounds Library Max ReFRAME Related Library

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Keywords

Olmesartan Medoxomil 144689-63-4 Endocrinology/Hormones RAAS Angiotensin Receptor CS 866 CS-866 CS866 inhibit Inhibitor Benicar inhibitor

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