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Oenothein B

Catalog No. TN6732 CAS 104987-36-2

Oenothein B is a specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B shows antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties.

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Oenothein B, CAS 104987-36-2

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Description	Oenothein B is a specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B shows antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties.
In vitro	Oenothein B (15-45 µM; 24 hours) not only increased the level of intracellular reactive oxygen species (ROS) but also induced the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax). Oenothein B (15-45 µM; 12-72 hours) had a dose- and time-dependent inhibition rate effect on A549 cells exposure. Oenothein B (15-45 µM; 24 hours) effectively inhibited the proliferation of A549 cells by inducing apoptosis and arresting cells at the G1 stage[3].
In vivo	In ICR mice, Oenothein B (100-300 mg/kg; p.o.) reduced neuroinflammation in the brain during systemic inflammation[2].

Molecular Weight	1569.08
Formula	C68H48O44
CAS No.	104987-36-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Satoru Tamura, et al. Oenothein B, dimeric hydrolysable tannin inhibiting HCV invasion from Oenothera erythrosepala. J Nat Med. 2019 Jan;73(1):67-75. 2. Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14(5):9767-78. 3. Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120.

Citations

1. Lee E J, Kim Y S, Kim J H, et al.Uncovering the colorectal cancer immunotherapeutic potential: Evening primrose (Oenothera biennis) root extract and its active compound oenothein B targeting the PD-1/PD-L1 blockade.Phytomedicine.2024: 155370.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Oenothein B 104987-36-2 Apoptosis Microbiology/Virology Proteases/Proteasome HCV Protease Antifungal Antibacterial antitumor HCV Hepatitis C virus ellagitannin antifungal antioxidant Bacterial inhibit Fungal glycohydrolase Inhibitor macrocyclic poly(ADP-ribose) anti-HCV anti-inflammatory inhibitor

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