Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 265.00 | |
50 mg | In stock | $ 392.00 | |
100 mg | In stock | $ 583.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 107.00 |
Description | ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer. |
Targets&IC50 | EP3 receptor:30 nM (Ki), FP:790 nM (Ki), TXR:2400 nM (Ki), EP4:1.3 nM (Ki) |
In vitro | ONO-AE3-208 abolishes CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid causes the dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208 [2]. |
In vivo | In mice, ONO-AE3-208 significantly reduces bone metastasis of PC3 cells in vivo, as evidenced by reduced photon tumor burdens over time when compared to the control group. Additionally, the rate of metastasis is significantly lower in the ONO-AE3-208-treated group, with a median metastasis formation time of 29 days, compared to 21 days in the control group. |
Synonyms | AE 3-208 |
Molecular Weight | 404.43 |
Formula | C24H21FN2O3 |
CAS No. | 402473-54-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 40 mg/mL (98.9 mM)
You can also refer to dose conversion for different animals. More
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ONO-AE3-208 402473-54-5 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor ONOAE3208 ONO AE3 208 AE 3-208 inhibit ONO-AE-3-208 Inhibitor inhibitor