Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydrochloride) binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 43.00 | |
25 mg | In stock | $ 81.00 | |
50 mg | In stock | $ 135.00 | |
100 mg | In stock | $ 239.00 | |
200 mg | In stock | $ 298.00 | |
500 mg | In stock | $ 491.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydrochloride) binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides. |
Synonyms | Naratriptan HCl, Amerge, Naramig, GR-85548A hydrochloride |
Molecular Weight | 371.93 |
Formula | C17H25N3O2S·HCl |
CAS No. | 143388-64-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20 mg/mL (53.8 mM)
DMSO: 69 mg/mL (185.5 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Naratriptan hydrochloride 143388-64-1 GPCR/G Protein Neuroscience 5-HT Receptor Naratriptan Hydrochloride Naratriptan HCl Inhibitor GR-85548A Hydrochloride GR-85548A Naratriptan Amerge Naramig 5-hydroxytryptamine Receptor Serotonin Receptor inhibit GR-85548A hydrochloride inhibitor