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Naltrexone hydrochloride

Catalog No. T0963 CAS 16676-29-2

Synonyms: Depade, Trexan, Naltrexone HCl, Antaxone

Naltrexone hydrochloride (Naltrexone HCl) is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.

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Naltrexone hydrochloride Chemical Structure

Naltrexone hydrochloride, CAS 16676-29-2

Pack Size	Availability	Price/USD
100 mg	In stock	$ 50.00
200 mg	In stock	$ 63.00
500 mg	In stock	$ 114.00

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Purity: 100%

Purity: 99%

Purity: 98.9%

Biological Description

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Description	Naltrexone hydrochloride (Naltrexone HCl) is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism.
Targets&IC50	Opioid receptor:8 nM
In vivo	Naltrexone (0.32 mg/kg) reduces ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%) in rhesus monkeys. Naltrexone (0.1 mg/kg) reduces ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. [1] Naltrexone (1-3 mg/kg) potently and dose-dependently inhibits reinstatement of ethanol-seeking produced by non-contingent deliveries of the liquid dipper filled with 8% ethanol. [2] Naltrexone elicits optimal enhancement of morphine's antinociceptive potency in mice when co-administered (i.p.) at about 100 ng/kg together with morphine (3 mg/kg). [3] Naltrexone (10 ng/kg i.p.) augments the antinociception produced by an acute submaximal dose of intrathecal (5 mg) or systemic (7.5 mg/kg i.p.) morphine in the tail-flick test in rats. Naltrexone combined with Morphine inhibits the decline in morphine antinociception and prevented the loss of morphine potency in rats. [4] Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels. [5] Naltrexone completely prevents the reduction in anogenital distance in prenatally stressed (PS) males and restores the growth rate of both sexes. Naltrexone also decreases the anxiety of PS rats in the plus-maze, increases the opioid component of exploration to control levels, but increases anxiety in control males. [6]
Kinase Assay	Chub-S7 cells are incubated in DMEM containing cold DHEA (20 nM) and tritiated DHEA (0.2 μCi/well) for 48 h. Following incubation, steroids are extracted using dichloromethane separated by thin-layer chromatography using n-hexane/1-hexanol (75:25) as the mobile phase system. Metabolites are identified by comigration with unlabeled reference steroids that are visualized by exposure to Lieberman-Burchard reagent (ethanol-acetic anhydride-sulfuric acid). Steroid conversion is quantified using a LabLogic AR-200 scanner. Protein concentration is measured using a colorimetric 96-well plate assay and used to normalize conversion. Activity is expressed as percent conversion[2].

Synonyms	Depade, Trexan, Naltrexone HCl, Antaxone
Molecular Weight	377.862
Formula	C20H24ClNO4
CAS No.	16676-29-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (145.56 mM)

H2O: 37.1 mM

References and Literature

1. Williams KL, et al. Psychopharmacology (Berl), 1998, 139(1-2), 53-61. 2. Bienkowski P, et al. Eur J Pharmacol, 1999, 374(3), 321-327. 3. Shen KF, et al. Brain Res, 1997, 757(2), 176-190. 4. Powell KJ, et al. J Pharmacol Exp Ther, 2002, 300(2), 588-596. 5. Gonzales RA, et al. J Neurosci, 1998, 18(24), 10663-10671.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library GPCR Compound Library NO PAINS Compound Library

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Keywords

Naltrexone hydrochloride 16676-29-2 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Depade Trexan Naltrexone HCl Naltrexone Hydrochloride Antaxone inhibitor inhibit

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