Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC305787 is an ezrin inhibitor(Kd of 5.85 μM), with antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 347.00 | |
25 mg | 6-8 weeks | $ 1,140.00 | |
50 mg | 6-8 weeks | $ 1,490.00 | |
100 mg | 6-8 weeks | $ 1,990.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 382.00 |
Description | NSC305787 is an ezrin inhibitor(Kd of 5.85 μM), with antitumor activity. |
Targets&IC50 | Ezrin:5.85 μM (kd), Ezrin:8.3 μM |
In vivo | NSC305787 mimicked the ezrin morpholino phenotype, and NSC668394 caused a unique developmental defect consistent with reduced cell motility in zebrafish.?Following tail vein injection of OS cells into mice, both molecules inhibited lung metastasis of ezrin-sensitive cells, but not ezrin-resistant cells.?The small molecule inhibitors NSC305787 and NSC668394 demonstrate a novel targeted therapy that directly inhibits ezrin protein as an approach to prevent tumor metastasis[1]. |
Molecular Weight | 445.42 |
Formula | C25H30Cl2N2O |
CAS No. | 785718-37-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (13.47 mM), Sonification and heating are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NSC305787 785718-37-8 Others NSC 305787 NSC-305787 inhibitor inhibit