Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 43.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 843.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure. |
In vitro | N106 (10 min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24 h in cardiomyocytes[1]. |
In vivo | N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10 mg/kg; i.v.) exhibits a half-life of 65.4 min and a Cmax of ∼2.24 μM[1]. |
Synonyms | N-106, N 106 |
Molecular Weight | 354.38 |
Formula | C17H14N4O3S |
CAS No. | 862974-25-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 56.7 mg/mL (160 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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N106 862974-25-2 Ubiquitination E1/E2/E3 Enzyme N-106 N 106 inhibitor inhibit