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Modecainide

Catalog No. T12087   CAS 81329-71-7
Synonyms: BMY 40327, MJ 14030

Modecainide is metabolite of Encainide, is an antiarrhythmic agent.

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Modecainide Chemical Structure
Modecainide, CAS 81329-71-7
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Modecainide is metabolite of Encainide, is an antiarrhythmic agent.
In vivo O-demethylated Encainide (MJ 9444) and 3-O-methoxy Encainide (MJ 14030), on cardiac conduction is studied by recording His bundle potentials in isolated perfused rabbit hearts and Purkinje and muscle conduction in vivo in dog hearts after destruction of the atrioventricular node. Both metabolites are 4 to 15 times more potent than Encainide in slowing conduction through the atria, the AV-node and the His-Purkinje system of the rabbit heart. In the dog, Encainide (0.8-3.2 mg/kg i.v.) slows conduction of extrasystoles in both Purkinje and muscle at all coupling intervals, increases the effective refractory period and the functional refractory period of the Purkinje pathway[1].
Synonyms BMY 40327, MJ 14030
Molecular Weight 368.47
Formula C22H28N2O3
CAS No. 81329-71-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Dresel PE. Effect of encainide and its two major metabolites on cardiac conduction. J Pharmacol Exp Ther. 1984 Jan;228(1):180-6.

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Keywords

Modecainide 81329-71-7 Others BMY-40327 MJ14030 BMY 40327 MJ 14030 MJ-14030 BMY40327 inhibitor inhibit

 

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