Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mericitabine (R-7128) is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 75.00 | |
5 mg | In stock | $ 183.00 | |
10 mg | In stock | $ 255.00 | |
25 mg | In stock | $ 441.00 | |
50 mg | In stock | $ 649.00 | |
100 mg | In stock | $ 926.00 | |
500 mg | In stock | $ 1,870.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 197.00 |
Description | Mericitabine (R-7128) is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication. |
In vitro | PSI-6130 is converted through phosphorylation by cellular kinases to an active 5′-triphosphate metabolite, which inhibits the NS5B RNA polymerase of HCV. Mericitabine is an oral cytidine nucleoside analog prodrug that exhibits strong antiviral effectiveness against the HCV polymerase across all HCV genotypes. Mericitabine is a first-in-class nucleoside polymerase inhibitor (NPI), which requires intracellular uptake and phosphorylation to two active triphosphates. Mericitabine, a cytidine analogue, is an oral prodrug of PSI-6130. PSI-6130 has an EC90 value of 4.6±2 μM in the HCV replicon assay. Mericitabine displays high specificity for HCV, minimal cytotoxicity, and does not affect mitochondrial DNA. Mericitabine shows a relatively good safety profile and significant potency against HCV-1 [2][3]. |
Synonyms | R-7128, RG 7128, PSI 6130 diisobutyrate |
Molecular Weight | 399.41 |
Formula | C18H26FN3O6 |
CAS No. | 940908-79-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (250.37 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Mericitabine 940908-79-2 Microbiology/Virology Proteases/Proteasome HCV Protease R 7128 R7128 inhibit PSI 6130 R-7128 RG7128 PSI6130 RG 7128 PSI-6130 Diisobutyrate HCV Inhibitor PSI 6130 Diisobutyrate RG-7128 PSI-6130 PSI6130 Diisobutyrate Hepatitis C virus PSI 6130 diisobutyrate inhibitor