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Men 10376 TFA(135306-85-3,free)

Catalog No. TP1086 CAS TP1086

Synonyms: Men 10376 TFA, Neurokinin-2 receptor antagonist TFA

Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.

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Men 10376 TFA(135306-85-3,free) Chemical Structure

Men 10376 TFA(135306-85-3,free), CAS TP1086

Pack Size	Availability	Price/USD
1 mg	In stock	$ 181.00
5 mg	In stock	$ 448.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,890.00

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Purity: 99.22%

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Description	Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
Targets&IC50	NK2:Ki: 4.4 μM (rat small intestine)
In vitro	Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
In vivo	Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].

Synonyms	Men 10376 TFA, Neurokinin-2 receptor antagonist TFA
Molecular Weight	1195.25
Formula	C59H69F3N12O12
CAS No.	TP1086

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 1.43 mg/mL (1.20 mM), Sonication is recommended.

References and Literature

1. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Peptide Compound Library GPCR Compound Library Membrane Protein-targeted Compound Library NO PAINS Compound Library

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Eledoisin Rolapitant C14TKL-1 acetate Neurokinin A Elinzanetant Talnetant Tradipitant Physalaemin

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Keywords

Men 10376 TFA(135306-85-3,free) TP1086 GPCR/G Protein Neuroscience Neurokinin receptor Men 10376 TFA(135306853,free) Men 10376 TFA Neurokinin-2 receptor antagonist TFA Men 10376 TFA(135306 85 3,free) inhibitor inhibit

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