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Membrane transporter/Ion channel Calcium Channel Manidipine dihydrochloride

Manidipine dihydrochloride

Catalog No. T0193   CAS 89226-75-5
Synonyms: CV-4093, Manidipine 2HCl
Purity 100.00% Datasheet

Manidipine dihydrochloride is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM).

Manidipine dihydrochloride, CAS 89226-75-5
Pack Size Availability Price/USD Quantity
25 mg In stock 50.00
50 mg In stock 60.00
100 mg In stock 96.00
200 mg In stock 171.00
1 mL * 10 mM (in DMSO) In stock 56.00
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Purity 100.00%
Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Manidipine dihydrochloride is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM).
Targets&IC50 Calcium Channel :ic50 2.6nM,  
Cell Research
The mitogenic effect is measured by the amout of [3H]thymidine incorporated into DNA of human MCs and by assessment of cell proliferation. In brief, 1 × 105 quiescent cells is seeded into a 25-mL cell culture bottle and kept in low serum medium (0.1% FCS). On the following day, the cells are preincubated for 3 hours with Manidipine (10 nM) followed by stimulation with PDGF-BB (10 ng/mL) or incubated with low serum medium abone. The medium is replaced each day, and the cells are counted at days 1, 3 and 5.(Only for Reference)
Cell lines: Mesangial cells
Animal Research
Animal Model: Normotensive Wistar-Kyoto rats and stroke-prone SHR
Synonyms CV-4093, Manidipine 2HCl
Purity 98.00%
Appearance solid
Molecular Weight 683.62
Formula C35H40Cl2N4O6
CAS No. 89226-75-5

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 20 mg/mL (29.3 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Tohse N, et al. Eur J Pharmacol, 1993, 249(2), 231-233. 2. Pfaffendorf M, et al. Am Heart J, 1993, 125(2 Pt 2), 571-577. 3. Iimura O, et al. Am Heart J, 1993, 125(2 Pt 2), 635-641. 4. Roth M, et al. Proc Natl Acad Sci, 1992, 89(9), 4071-4075. 5. Kakihana M, et al. Jpn J Pharmacol, 1988, 48(2), 223-228. 6. Morimoto S, et al. Jpn J Pharmacol, 1989, 51(2), 257-265. 7. Okabe K, et al. J Pharmacol Exp Ther, 1987, 243(2), 703-710.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-diabetic Compound Library Autophagy Compound Library Ion Channel Inhibitor Library Anti-Cardiovascular Disease Compound Library

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Related compounds with same targets
Dantrolene sodium salt Diltiazem hydrochloride Nitrendipine Azelnidipine Felodipine Nisoldipine Levetiracetam Manidipine dihydrochloride

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