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Macranthoside B

Catalog No. T5787 CAS 146100-02-9

Macranthoside B Iis a natural product isolated from Flos Lonicerae, possesses anti-bacterial activity.

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Macranthoside B, CAS 146100-02-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 46.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 150.00
25 mg	In stock	$ 249.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 548.00

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Purity: 98.07%

Biological Description

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Description	Macranthoside B Iis a natural product isolated from Flos Lonicerae, possesses anti-bacterial activity.
In vitro	Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo[1].
Cell Research	The anticancer effect of Macranthoside B both in vitro and in vivo using cell proliferation assays and xenograft tumor growth assays. Macranthoside B inhibits the proliferation of various kinds of cancer cells with IC(50) values in the range of 10-20 microM. Moreover, the volume and weight of xenograft tumors in nude mice treated with 5mg/kgMacranthoside B were decreased remarkably compared to those of the vehicle control group. Furthermore, DAPI staining and flow cytometry analysis with Annexin V/PI double staining revealed that more apoptotic cells were observed following Macranthoside B treatment. In addition, degradation of PARP (poly-ADP-ribose polymerase), and activation of the caspase cascade for intrinsic pathways were observed. The expression of Bcl-2 protein decreased and the protein level of Bax increased which leading to an increase of the Bax/Bcl-2 ratio. Macranthoside B exhibited strong anti-tumor effect and mitochondrion-mediated apoptosis induction involved in it[1].
Source	Natural Products > Caprifoliaceae > Lonicera

Molecular Weight	1075.24
Formula	C53H86O22
CAS No.	146100-02-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Wang J , Zhao X Z , Qi Q , et al. Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo[J]. Food & Chemical Toxicology, 2009, 47(7):0-1721. 2. Shan Y , Guan F , Zhao X , et al. Macranthoside B induces apoptosis and autophagy via reactive oxygen species accumulation in human ovarian cancer A2780 cells[J]. Nutrition and Cancer, 2016:1-10.

Related compound libraries

This product is contained In the following compound libraries：

Drug-induced Liver Injury (DILI) Compound Library Anti-Tumor Natural Product Library Bioactive Compounds Library Max Anti-Infection Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Saccharide and Glycoside Natural Product Library Natural Product Library for HTS NO PAINS Compound Library Anti-Bacterial Compound Library

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Keywords

Macranthoside B 146100-02-9 Microbiology/Virology Antibacterial Bacterial Inhibitor inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.