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ML277

Catalog No. T3303 CAS 1401242-74-7

Synonyms: ML-277, CID-53347902

ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).

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ML277, CAS 1401242-74-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
5 mg	In stock	$ 71.00
10 mg	In stock	$ 132.00
25 mg	In stock	$ 245.00
50 mg	In stock	$ 453.00
100 mg	In stock	$ 667.00
1 mL * 10 mM (in DMSO)	In stock	$ 91.00

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Purity: 99.97%

Biological Description

Chemical Properties

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Description	ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
Targets&IC50	K+ channel:270 nM
In vitro	ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. IC50 value: 270 nM (EC50) [1] Target: K(v)7.1 activator ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel[1].

Synonyms	ML-277, CID-53347902
Molecular Weight	471.59
Formula	C23H25N3O4S2
CAS No.	1401242-74-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56 mg/mL (118.75 mM)

References and Literature

1. Mattmann ME, Yu H, Lin Z, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012;22(18):5936-5941. doi:10.1016/j.bmcl.2012.07.060 2. Robbins J, et al. Pharmacol Ther. 2001 Apr;90(1):1-19. 3. Mattmann ME, et al. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41. 4. Yu H, et al. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8732-7. 5. Wulff H, et al. Nat Rev Drug Discov. 2009 Dec;8(12):982-1001.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Ion Channel Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Potassium Channel Blocker Library Anti-Cancer Compound Library

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Keywords

ML277 1401242-74-7 Membrane transporter/Ion channel Potassium Channel CID53347902 CID 53347902 inhibit ML 277 Inhibitor KcsA ML-277 CID-53347902 inhibitor

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