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ML 254

Catalog No. T8862   CAS 1428630-86-7

ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents.

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ML 254 Chemical Structure
ML 254, CAS 1428630-86-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 51.00
5 mg In stock $ 122.00
10 mg In stock $ 197.00
25 mg In stock $ 455.00
50 mg In stock $ 672.00
100 mg In stock $ 956.00
1 mL * 10 mM (in DMSO) In stock $ 157.00
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Purity: 99.94%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents.
Targets&IC50 rat mGluR5:8.03 nM (pEC50), rat mGluR5:9.3 nM (EC50)
Molecular Weight 310.32
Formula C18H15FN2O2
CAS No. 1428630-86-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (88.62 mM)

TargetMolReferences and Literature

1. Zhou Y , Chun A , Gogliotti R D , et al. Pure Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction[M]// Probe Reports from the NIH Molecular Libraries Program. PubMed, 2010.

Related compound libraries

This product is contained In the following compound libraries:
Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Covalent Inhibitor Library Bioactive Compound Library

Related Products

Related compounds with same targets
S-(4-Hydroxybenzyl)glutathione L-Cysteic acid monohydrate JNJ-46778212 LY339434 HCl MTEP hydrochloride mGluR3 modulator-1 XAP044 VU 0469650

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Keywords

ML 254 1428630-86-7 Neuroscience GluR inhibit Inhibitor Metabotropic glutamate receptors mGluR ML-254 Schizophrenia ML254 inhibitor

 

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