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Neuroscience NMDAR MDL 29951

MDL 29951

Catalog No. T1897   CAS 130798-51-5

MDL-29951 is a novel glycine antagonist of NMDA receptor activation.

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MDL 29951, CAS 130798-51-5
Pack Size Availability Price/USD Quantity
1 mg In stock 88.00
2 mg In stock 122.00
5 mg In stock 184.00
10 mg In stock 319.00
25 mg In stock 575.00
50 mg In stock 946.00
100 mg In stock 1471.00
1 mL * 10 mM (in DMSO) In stock 184.00
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Purity 99.22%
Purity 99.49%
Biological Description
Chemical Properties
Storage & Solubility Information
Description MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
Targets&IC50 NMDA receptor
Kinase Assay [3H]JCPP (30.7 Ci/mmol) binding assays are conducted in minivials, incubated for 15 mm at 25°C in 1 mL of 50 mM Tris-HC1 (pH 7.4) containing 10 nM [3H]JCPP, 200 g of membrane protein and unlabeled ligands as indicated. Nonspecific binding is defined using 1 mM L-glutamate. Bound ligand is separated by centrifugation. Specific binding accounted for approximately 80% of total binding.
Molecular Weight 302.11
Formula C12H9Cl2NO4
CAS No. 130798-51-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Baron BM, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. 2. Wright SW, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. 3. Harden TK. Enigmatic GPCR finds a stimulating drug. Sci Signal. 2013 Oct 22;6(298):pe34.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Neuronal Signaling Compound Library Ion Channel Inhibitor Library Neurotransmitter Receptor Compound Library Target-Focused Phenotypic Screening Library Anti-Neurodegenerative Disease Compound Library Anti-Alzheimer's Disease Compound Library

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