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MDL 19301

Catalog No. T11981 CAS 89388-38-5

MDL 19301 is a nonsteroidal, anti-inflammatory agent.

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MDL 19301, CAS 89388-38-5

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Biological Description

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Description

MDL 19301 is a nonsteroidal, anti-inflammatory agent.

In vivo

MDL 19301 exhibits additional anti-inflammatory effects by inhibiting carrageenan pleurisy, adjuvant arthritis, and HOAc-induced writhing. Pharmacologically, it suppresses prostaglandin synthesis, blocks arachidonic acid-induced diarrhea (excluding prostaglandin-E2-caused), and prevents arachidonic-acid-stimulated rat platelet aggregation (excluding ADP-induced). Contrary to expectations, both MDL 19301 and MDL 16,861 show minimal antipyretic effects in rats. Remarkably, oral MDL 19301 administration reduces rat paw edema significantly, induced either by carrageenan (ED30=4.8 mg/kg) or an Arthus reaction (ED30=8.2 mg/kg p.o.), and does not cause gastric ulceration in fasted rats at doses up to 1,000 mg/kg, indicating a better therapeutic index than traditional non-steroidal anti-inflammatory drugs (NSAIDs). The anti-inflammatory effect of MDL 19301 (unlike MDL 16,861) diminishes with SKF525A co-administration, suggesting MDL 19301's prodrug status for MDL 16,861 and its lower ulcerogenic potential.

Molecular Weight	279.46
Formula	C15H21NS2
CAS No.	89388-38-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. NS Doherty, et al. Pharmacological properties of MDL 19,301: A novel, nonsteroidal, anti‐inflammatory agent. Drug Dev Res 1989 16(1) 31-44

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MDL 19301 89388-38-5 Others MDL19301 MDL-19301 inhibitor inhibit

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