Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 2,120.00 | |
50 mg | 8-10 weeks | $ 2,780.00 | |
100 mg | 8-10 weeks | $ 3,700.00 |
Description | MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM). |
Targets&IC50 | MARK:5 nM |
In vitro | MARK-IN-2 inhibits MARK3 with an IC50 of 5 nM. MARK-IN-2 also inhibits MARK3 in primary cell culture of rat cortical neurons with an IC50 of 280 nM.MARK-IN-2 is a potent MARK inhibitor.?Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. |
In vivo | MARK-IN-2 has moderate terminal elimination half-life (t1/2=0.7 h, and 1 h for rat and dog) .Characterization of the i.v. pharmacokinetic properties of MARK-IN-2 in rat and dog reveals reasonable volumes of distribution but moderate to high clearance and short half-lives. |
Molecular Weight | 425.88 |
Formula | C18H18ClF2N5OS |
CAS No. | 1314893-26-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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MARK-IN-2 1314893-26-9 Others MARK IN 2 MARKIN2 inhibitor inhibit