Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lofexidine is a selective α2-receptor agonist, Lofexidine reduces narcotic withdrawal symptoms.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 30.00 | |
50 mg | In stock | $ 85.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Lofexidine is a selective α2-receptor agonist, Lofexidine reduces narcotic withdrawal symptoms. |
In vivo | Lofexidine significantly decreased SOWS scores compared to placebo and demonstrated better retention rates in participants undergoing opioid withdrawal. Lofexidine potentially offers a useful non-opioid alternative to treat opioid withdrawal symptoms[1]. |
Animal Research | 8-day, randomized, double-blind, placebo-controlled, parallel-group study in 264 patients dependent on short-acting opioids evaluated the efficacy of lofexidine hydrochloride in reducing withdrawal symptoms in patients undergoing opioid withdrawal.?The primary efficacy measures were SOWS-Gossop on Day 3 and time-to-dropout.?Secondary endpoints included the proportion of participants who were completers;?area under the 5-day SOWS-Gossop - time curve (i.e., AUC1-5), and daily mean SOWS-Gossop, OOWS-Handelsman, MCGI (subject and rater), and VAS-E scores.?Participants received lofexidine HCl 3.2mg daily in four divided doses or matching placebo on Days 1-5, followed by 2days of placebo[1]. |
Molecular Weight | 259.13 |
Formula | C11H12Cl2N2O |
CAS No. | 31036-80-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (241.19 mM)
You can also refer to dose conversion for different animals. More
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Lofexidine 31036-80-3 GPCR/G Protein Neuroscience Adrenergic Receptor inhibit Inhibitor Beta Receptor inhibitor